As the name “unexplained infertility” implies, this condition occurs when no obvious cause(s) for a couple’s infertility can be found. This is much different than stating “there is no cause.” This is perhaps one of the most frustrating “diagnoses” because there is no specific organ system that can be targeted for treatment. However, it is one of the most successfully treated diagnoses.
There is certainly a cause of infertility in the female, the male, or both but science had not progressed to the point where it can be identified. Researchers and physicians are still delineating the many processes that must successfully occur for a successful pregnancy to result. As time passes, and new studies are evaluated, the number of cases falling into the “unexplained infertility” category continues. Also, when care is sought from a Reproductive Endocrinologist/Fertility specialist a "cause(s)" for a couple's infertility is more likely to be found".
Many believe that a major portion of unexplained infertility cases are due to genetic abnormalities in the egg and or sperm. There may be unidentified genetic “diseases” that inhibit successful fertilization of the egg and embryonic development.
Sometimes these couples will undergo stimulated IUI as a “first line” treatment. This depends upon factors such as age and previous treatments. IVF may also be considered a primary treatment in many patient types.
One advantage of IVF is that it allows the fertility specialist and embryologist to visually document successful fertilization and cell division. This is possible because the sperm an egg are combined in a Petri dish where fertilization occurs.
Couples can have confidence that even unexplained infertility is usually successfully treated.